PDA

View Full Version : PPCM Registry - LDS Hospital


Erin
12-27-2007, 03:26 PM
For those who have participated, following is a note I received recently from Research Coordinator Ashli Zeigler re: the PPCM registery conducted by LDS Hospital and Utah affiliated hospitals:

"I just wanted to give you an update on the project.

We have collected over 40 DNA samples and have sent them off to be analyzed. As soon as we get the results (possibly 2 months from now) we can research them and try to determine if there is any genetic link. This process is lengthy and may take several months to a year to yield a response.

We did begin a local support group that met in Salt Lake City Utah. But nothing has become available as far as a website support group.

I will keep you posted if that changes."

For more information, please contact Ms. Zeigler at Ashli.zeigler@intermountainmail.org and see article below:

Deseret Morning News, Saturday, February 10, 2007

LDS Hospital studying heart ailment

Women can develop condition during or following pregnancy

By Lois M. Collins
Deseret Morning News

LDS Hospital's Heart Failure Prevention and Treatment Program has launched a registry to collect scientific data on a type of cardiomyopathy associated with pregnancy.


Dr. A.G. Kfoury

"There's not a lot of scientific data on peripartum cardiomyopathy," said Jennifer Connolly, nurse practitioner in the program.

Through the registry, the program will collect blood samples for analysis, looking for genetic tendencies and links. The researchers hope to find common identifying factors between patients with the disease and therapies that help with both treatment and prognosis.

Heart failure is the topic of today's Deseret Morning News/Intermountain Healthcare Hotline. From 10 a.m. to noon, Connolly and a cardiologist in the program, Dr. A.G. Kfoury, will take phoned-in questions. All calls are confidential.

Heart failure is a common medical condition, and the risk of developing it increases with age, says Kfoury. The symptoms of peripartum cardiomyopathy are the symptoms of heart failure: shortness of breath, fatigue and evidence on an echocardiogram that the heart muscle is failing.

Pregnancy-related cardiomyopathy, which may appear in the final month of pregnancy up to five months after, is a mystery. Doctors and researchers don't understand the cause, and there's conflicting data on whether it's safe for a woman who has developed it to have another baby.

"Generally speaking, unless she's fully recovered, we don't recommend it. Maternal mortality greatly increases if she gets pregnant and has another baby after an episode from which the heart never recovered," Connolly says.

Some women are fine, while others die. "We're just starting to learn what makes the difference."

Researchers would like to learn how to prevent cardiomyopathy and to identify those at risk early. So they're reaching through the Intermountain Healthcare network and beyond to find the women who may hold the key to understanding the condition — those who have experienced it.

One goal is to try and understand the differences that lead to different outcomes. Why do some women recover completely from the pregnancy-related heart problem, while others do not?

The researchers are also trying to form a support group for women who have the disease, which has been nicknamed PPCM.

Anyone interested in contributing to the database can e-mail either kim.allan @intermountainmail.org or Ashli.zeigler@intermountainmail.org.

4girlsmama
12-28-2007, 06:27 PM
Lois Collins, the reporter for the Desert News is a good friend of mine. she is so in the loop on PPCM and a heart patient herself (not ppcm), Her daughter has also had heart surgery. This is a great source:) Thanks for getting it out there.

Erin
12-30-2007, 01:02 PM
Lois Collins, the reporter for the Desert News is a good friend of mine. she is so in the loop on PPCM and a heart patient herself (not ppcm), Her daughter has also had heart surgery. This is a great source:) Thanks for getting it out there.

It's a small world! Do you by chance have an email address for Lois that you could pass on to me? I'd love to thank her for doing the article and ask her if she plans to do a follow-up when results come back next year.

Thanks.

4girlsmama
12-30-2007, 09:47 PM
Erin here is Lois's e-mail: I hope it's helpful lois@desnews.com

Erin
12-31-2007, 11:27 AM
Thank you!

SusanD
01-01-2008, 09:45 AM
Thanks for the update ! I'm wondering if anyone knows about the revealing of outcomes of the study? Since this is not a treatment intervention type of study, I would think we would be told of our individual outcomes (i.e. any genetic link found for each of us ) rather than just hearing the outcomes of the whole study per se.

Does anyone know?

Erin
01-05-2008, 09:51 AM
Thanks for the update ! I'm wondering if anyone knows about the revealing of outcomes of the study? Since this is not a treatment intervention type of study, I would think we would be told of our individual outcomes (i.e. any genetic link found for each of us ) rather than just hearing the outcomes of the whole study per se.

Does anyone know?

Thanks for asking about this, Susan. I just spoke with Ashli again, and she said that if there are any results that are significant to the individual’s clinical course and/or DNA sample, we will be informed. So yes, we can find out about our individual outcomes. And of course, all who participated in the registry will be told the overall results of the study once it is completed as well.

It will be very interesting, I'm sure.

Lacey
12-29-2008, 11:29 PM
HOw did they pick the women to participate in the clinical study???

Erin
12-30-2008, 09:49 AM
HOw did they pick the women to participate in the clinical study???

The women volunteered. That's why it's very important that any of you who desire to should contact Kim at Intermountain Med Center to volunteer your participation in the registry. We need as many volunteer participants as we can get! You may email Kim or call her (she prefers email) at the following:

Kim Brunisholz, Research Associate
kim.brunisholz@imail.org
office: 801-507-4777

Thanks!

Lacey
12-30-2008, 09:28 PM
Do we just give our dna or do we have to travel out of state?? Can you give me alittle more detail please and thank you..

Erin
12-31-2008, 09:52 AM
Thanks for asking this question, Lacey. Volunteers (you all) can participate in this PPCM Registry in two ways.

One, you can submit data from your medical records, and Kim from Intermountain will send you forms and instructions after you contact her.

Two, Kim will mail you a package that includes a consent form, a medical release form, and a blood draw kit that you take to your health care provider or to a lab. They draw your blood and it gets submitted for analysis. They're looking for any genetic clues that reveal more about PPCM. Very important.

When you email Kim, she'll walk you through either or both processes, depending on what you want to do. I did both parts of the study when I registered, as did many other women here. It's easy and doesn't take much time. Kim is always available by email or phone to answer questions or help if you have any trouble.

Please feel free to ask me any other questions you have. Please keep the emails coming, and thank you to those who are copying emails to me when you contact Kim. It's awesome that you are all willing to sacrifice your time (and blood!) to forward research about PPCM. Thank you.

LovinLife
01-01-2009, 01:14 PM
My kit is on the way! Yay! I talked with Kim on the phone yesterday, but it's my understanding that you've spoken with her a lot more. Do you know if they're finding any genetic links? We went through everything so fast and now it's all kind of jumbled in my brain...go figure :) I'm thinking she said they think they've found genetic markers but have to get more samples for it to be considered "proven"....is that right? Can you tell us everything you know about what the research has found thus far? I'm excited to be a part of it. It makes me feel like I can turn my experience into something positive, so other women may not have to suffer through this one day!

Erin
01-08-2009, 09:35 AM
They have found some evidence, but the scientists can't reveal anything until they have more volunteers to substantiate their findings. So glad you're getting involved!

LovinLife
01-08-2009, 12:15 PM
so you don't know what the evidence is? Sorry, I'm so nosey :) I'd just like to know what they're thinking, even if it isn't proven yet :)

Erin
01-08-2009, 10:31 PM
You're just funny! :) The best I can tell you is that after the initial eval, their scientists have discovered a few genetic variables involved in PPCM, which is promising -- but we need more volunteers!

Who else is willing to help? Please email me at martineau.erin@gmail.com or Kim at kim.brunisholz@imail.org. Thanks, ladies.

Thanks for your questions, Tish!